Upperton Pharma Solutions now has a fully commissioned
60 square metre non-GMP pilot plant, mirroring our GMP manufacturing facility.
The pilot plant is equipped for three scales of spray drying:
• ProCept 4M8-Trix for batch sizes of up to 300g
Intermediate Spray Dryer for batch sizes of up to 1kg
Niro Mobile Minor for batch sizes of up to 3kg
In addition, the pilot plant has all of the powder
handling and processing capabilities offered in our GMP manufacturing facility,
for downstream processing of spray dried powders into final dosage forms.
Formulations and processes optimised in our R&D
laboratories can be quickly scaled up to produce non-GMP material for
toxicology and stability studies and CMC batches. The mirroring of our GMP
capability enables a rapid seamless transfer of processes into clinical
manufacture, along with all of the expertise and formulation-specific know-how
built up during the development stages.
In 2014, Upperton Pharma Solutions was awarded a
prestigious Horizon 2020 grant as part of a European consortium led by Mymetics, a pioneering company at the forefront of the development
of virosome-based vaccines.
The MACIVIVA goal was to develop dry powder, thermostable, cold-chain
independent virosomal vaccine formulations for non-invasive needle-free
administration. Such solid form vaccines should reduce the cost and improve safety
and compliance in National Immunisation Programs, particularly in the developing
The Upperton formulation development team successfully developed spray dried
formulations of HIV virosomal vaccines for both oral and nasal delivery routes.
The optimised processes were scaled up and transferred into the company’s GMP
clean room facility, where batches of both the Oral and the Nasal formulation
Upperton’s spray dried Virosomal Vaccine
- Retained virosome structure and
particle size on spray drying
- Preserved antigenicity in the
final solid vaccine forms
- Retained the initial vaccine
immunogenicity after storage for three months at 40°C / 75%RH
- Both nasal and oral formulations
were successfully dosed in animal models
- The immunogenicity of the nasal
solid vaccine form was comparable to subcutaneous injection of the
reference liquid vaccine
Participation in the MACIVIVA
project has enabled Upperton to expand their technical capabilities to include
GMP manufacture of solid form virosomal vaccines.
Successful Completion of N2 Business Growth Grant
In October 2017, Upperton was delighted to be awarded grant
funding by the Nottinghamshire-based N2 Business Growth Fund to support
investment into a capital project leading to business growth and the creation
of new sustainable jobs. Upperton used the funds to support the establishment
of a GMP clinical manufacturing capability at its Nottingham site.
The success of the project was easily measured:
In November 2018 Upperton Pharma Solutions’ manufacturing facilities passed
inspection by the UK Medicines and Healthcare products Regulatory Agency. The
MHRA licence allows the company to develop pharmaceutical formulations for
oral, nasal and pulmonary delivery right through from early feasibility studies
to scale up and Phase I & II clinical manufacture, all from its Nottingham
Science and Technology Park site.
Upperton Pharma Solutions’ new pharmaceutical spray drying manufacturing facilities at Nottingham Science and Technology Park have successfully passed inspection by the UK
Medicines and Healthcare products Regulatory Agency (MHRA).
A pharmaceutical spray drying contract development and manufacturing organisation (CDMO),
Upperton Pharma Solutions moved to its new facilities on Nottingham Science and Technology Park from its previous headquarters at BioCity Nottingham in March 2018, as part of a planned expansion of its services.
The company has invested heavily in the new facilities both in terms of building enhancements and in the expansion of its processing and analytical
The successful MHRA inspection provides Upperton Pharma Solutions with the
necessary MHRA licenses for manufacture, downstream processing into capsules
and tablets, as well as release of spray dried formulations of Biotherapeutics and small molecule APIs for clinical trials.
The company is now able to develop pharmaceutical formulations for oral, nasal and pulmonary delivery from early feasibility studies to Phase I & II clinical manufacture, from its Nottingham Science and Technology Park site.
Richard Johnson, CEO and Founder of Upperton Pharma Solutions, said: “We are absolutely delighted with the expansion of our capabilities in GMP clinical manufacturing and look forward to seeing our clients’ projects progress within Upperton, from early formulation development studies right through to clinical manufacture.”
“The positive endorsement by the MHRA will enable a seamless transition from R&D to GMP manufacture within the organisation, ensuring that all of the
project-specific knowledge and expertise developed in R&D will flow through to the GMP manufacturing processes.”
Paul Kelsall, Director of Clinical Trials Manufacturing commented: “This is a great opportunity for our business and is a result of our team’s commitment to
achieve the targets and aspirations of our business. We are looking forward to working with our clients and offering services from early stage development
through to clinical manufacture. These are exciting times for Upperton as we
continue to move forward and expand our capabilities.”
To learn more visit our GMP page
Upperton Pharma Solutions: At a time when the global CDMO market place is consolidating, Upperton Pharma Solutions remains as one of the few independent CDMO service providers with a specific focus on developing pharmaceutical
dosage forms using its specialised spray drying capabilities. Upperton provides a range of integrated services to the pharmaceutical and biotech sectors around the world. The services include: early feasibility studies, formulation
development for both small molecule APIs and Biotherapeutics for a range of
final dosage forms and GMP manufacture of materials for Phase I & II
clinical trials. Full analytical support, including ICH stability studies,
The company is a privately-owned
organisation that has grown organically over almost 20 years and now employs 24 highly skilled personnel. Upperton Pharma Solutions has its headquarters in
Business Development Associate
Upperton Pharma Solutions, Albert Einstein Centre, Nottingham Science & Technology Park
Nottingham NG7 2TN
T: +44 (0) 115 855 7050 (Monday to Friday 8.30am – 4.30pm)