Example: Extending the half life of an MRI contrast agent

In its natural state, gadolinium chelate is rapidly excreted from the circulation due to its small molecular weight. The agent has a circulatory half life of less than 30 seconds. The chelate can be seen accumulating in the kidneys and bladder within a few seconds, following intravenous injection.

MRI scan showing rapid blood-pool clearance of low-molecular weight MRI contrast agent

Using the rP-conjugate^TM technology, gadolinium chelate is chemically linked to Recombumin^®, resulting in a significant enhancement of its circulatory half-life. The gadolinium chelate is present in the bloodstream for prolonged periods, with little or no sign of renal clearance.

MRI scan showing extended blood pool half-life of MRI contrast agent chemically linked to Recombumin^® using the rP-conjugate^TM technology