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Albumin as a carrier Human albumin is the most abundant protein in the human body. Present at concentrations as high as 40g/L, one its main functions is to act as a carrier for a wide range of molecules. These include fatty acids, salts and a wide variety of drugs which are known to bind to the albumin molecule at a number of binding sites present in the globular structure of the protein. Once bound, drugs and other agents can be transported around the body, often remaining in circulation for many days. These properties are now being exploited by Upperton to enhance the delivery of drugs, proteins and peptides that normally have a short circulatory half life. The Upperton technology is based on Recombumin®, the world’s only recombinant human albumin approved by the FDA/EMEA for human administration. The Recombumin® molecule is derived from the yeast Saccharomyces cerevisiae and is free from animal derived material. rP-conjugateTM: albumin conjugation chemistry The Recombumin® molecule has a number of potential sites where drugs, peptides or other molecules can either bind naturally or be attached covalently. These linkages can be designed to release the active molecule either slowly or quickly, depending on the chemical environment in different parts of the body. schematic showing how the rP-conjugateTM technology can be used to achieve high pay-loads of drug linked to albumin carriers
Once linked to albumin, the conjugated drug will have an extended half life following intravenous administration. Albumin fusion is an alternative method for peptides/proteins to be linked to albumin. For such compounds Upperton’s conjugation technology offers several major advantages:
More information on rP-conjugateTM: applications
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