Producing precisely-sized nanoparticles from proteins

Upperton’s next generation technology for producing nano-sized particles from peptides and proteins (including monoclonal antibodies and enzymes) and other biomolecules with suitable reactive side chains offer unique competitive advantages

Controlled Size Distribution (Recombinant Albumin)

Key attributes:

• Size can be precisely controlled from 10nm to 120nm
• Size allows sterile filtration through 0.2µm filter
• Proteins in particles are not denaturated; protein specific active membrane and barrier crossing properties are retained
• Particles are very stable in suspension and amenable to freeze-drying

Simplicity of manufacturing:

The rP-nano^TM production process is very robust, simple and reproducible. Currently working at gram scale, we envisage a seamless transition to commercial production without loss of size-control.

Loading of nanoparticles:

Our nanoparticles have already been loaded with a wide range of pharmaceutical, biotechnology and diagnostic agents. This can be achieved using a number of approaches that include chemical conjugation or simple protein binding/adsorption.

For proof of concept we have generated nanobiomolecules from:

• Recombinant human albumin (rHA)
• Recombinant transferrin
• Apo A1 (apolipoprotein A-1)
• Monoclonal Antibodies

More information on rP-nano:^TM applications | collaborations

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