Events

DDL Edinburgh, 11th to 13th December 2019

Upperton will be exhibiting at Drug Delivery to Lung (DDL) in Edinburgh this December, to showcase their pulmonary delivery capabilities and technical knowledge. Attending DDL, at Booth 144, on behalf of Upperton are: Dr Andrew Naylor Director of R&D, Sarah Bayliss Director of Quality & Compliance and Klara Fisken Business Development Associate.

We are looking forward to meeting both new and existing clients on our stand. So if you have an API which requires drug delivery to the lungs, please contact us to book an appointment or alternatively drop by our exhibition stand to talk to Upperton’s DDL team.

RS01 monodose dry powder inhaler from Plastiape for Drug Delivery to the Lung (DDL)

Poster Presentation

Andrew Naylor will be presenting a poster, titled “Novel inhaled treatment for Cystic Fibrosis, manufactured using a combination process of spray drying and micronisation”.

Cystic fibrosis (“CF”) is a life-limiting disease characterised by the build-up of thick mucus in a number of organs including the linings of the lungs; creating an ideal environment for bacterial infection and colonization. CF patients generally undergo intensive, long-term antibiotic therapy, resulting in unavoidable resistance to many anti-infective drugs. Lynovex® is a novel, highly differentiated single therapy for the treatment of various CF-associated lung disease symptomology using cysteamine bitartrate as the active ingredient. The treatment has a unique multi-action, breaking down the excessive mucus produced by the lining of the airways, having antimicrobial activity against bacteria responsible for the recurrent respiratory infections (anti-virulence, anti-biofilm and antibiotic potentiating) associated with CF. Lynovex® is intended for use alongside future standard of care therapy (including CFTR modulators) as a new treatment paradigm for CF. The delivery of maintenance treatments locally to the site of action allows lower ongoing doses to be used, and in the case of CF, local delivery is achieved via an inhaled dry powder delivered to the lung. In this work we demonstrate using the combination of spray drying and micronisation as a manufacturing process to produce particles uniform in size and composition, whilst maintaining an efficient process. The Lynovex® formulation produced shows excellent aerosolization properties, stability and in vitro efficacy. Patient benefits of this approach include improved compliance and acceptance, and a reduced systemic drug loading during treatment.

Upperton's Team

Andrew Naylor
R&D Director

Dr Andrew Naylor was appointed R&D Director for Upperton Pharma Solutions in August 2015, having previously held the position of Head of Process Development at Critical Pharmaceuticals. Andrew holds a Masters and PhD degrees in Chemistry from the University of Nottingham. Andrew has extensive experience in the development and analysis of pharmaceutical products and has sat on several Royal Society of Chemistry special interest group committees in the fields of polymer and materials science.

Sarah Bayliss
Director of Quality & Compliance

Sarah Bayliss joined Upperton in December 2017 as Director of Quality and Compliance. Her previous roles include Corporate QA Operations Manager, Head of Quality, Technical Manager and General Manager for pharmaceutical and medical device businesses within the manufacturing areas of Europe and the USA. Sarah has over 20 years’ experience of implementing, maintaining and remediating Quality Management Systems, working under MIA, IMP, MS and WD licences. Sarah is responsible for ensuring that Upperton Pharma Solutions are compliant and that our Quality Management Systems are implemented and adhered to in-line with the site relevant licensing activities (GMP) under MHRA & FDA regulations.

Klara Fisken
Business Development Associate

Klara Fisken joined Upperton in August 2018, after completing a three month project at Upperton which was part of her MSc in Applied Biopharmaceutical Biotechnology and Entrepreneurship from the University of Nottingham. Klara is responsible for Upperton’s marketing which includes newsletters, creating marketing materials, press releases, website and social media. 

DDL Conference

The Drug Delivery to the Lungs (DDL) Conference provides an annual forum for scientists, academics, clinicians, regulatory and industry specialists involved in developing medicines for inhalation. Providing a full programme of lectures, access to scientific posters and an industry exhibition.