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11th February 2020 – Tablets: A General Formulation Overview

News 11th February 2020 – Tablets: A General Formulation Overview Tablets continue to be one of the most popular pharmaceutical dosage forms due to their ease of handling and administration for patients, stability convenient packing options, and well-established cost-effective manufacturing processes which produce consistent quality products. However, there are also disadvantages which can include: poor …

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28th January 2020 – Tablets: A General Overview

News 28th January 2020 – Tablets: A General Overview Tablets are one of the most popular dosage forms used in the pharmaceutical industry due to their: ease of handling and administration for patients, stability, convenient packing options and well-established cost-effective manufacturing processes which produce consistent quality products. However, there are also disadvantages to presenting a …

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14th January 2020 – Oral Solid Dosage Forms Containing Amorphous Spray Dried Dispersions: Choices for First in Human Studies

News 14th January 2020 – Oral Solid Dosage Forms Containing Amorphous Spray Dried Dispersions: Choices for First in Human Studies The number of amorphous solid dispersions entering first in human (FIH) studies continues to increase, due to the growing number of novel APIs with a poor solubility profile, and associated bioavailability challenges. Spray drying is …

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19th December 2019 – Season’s Greeting and End of Year Review

News 19th December 2019 – Season’s Greetings and End of Year Review Season’s Greetings and a Happy New Year to all of our Customers and our industry contacts from everyone at Upperton Pharma Solutions! Once again, we head towards the year-end holiday break with the Upperton team continuing to work at full capacity to ensure …

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12th December 2019 – Assessing Bioavailability Enabling Technologies using Upperton Pharma Solutions Screening Platform – UpperSolv™+

News 12th December 2019 – Assessing Bioavailability Enabling Technologies using Upperton Pharma Solutions Screening Platform – UpperSolv™+ Currently approximately 9 out of 10 new drugs entering clinical trials will fail before reaching approval. Many of these drugs will fail due to problems with ADME (absorption, distribution, metabolism and excretion) rather than lack of efficacy. One …

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4th December 2019 – Using Spray Drying to Develop Inhaled Dosage Forms

News 4th December 2019 – Using Spray Drying to Develop Inhaled Formulations Pulmonary delivery is showing increased popularity as a viable dosage form for treating local airway diseases and offers additional potential for systemic drug delivery. Within this space there are a number of delivery approaches that can be undertaken. These include dry powder inhaled …

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28th November 2019 – Selecting a Spray Dryer for Development Studies and Clinical Manufacture

News 28th November 2019 – Selecting a Spray Dryer for Development Studies and Clinical Manufacture When customers initiate discussions with Upperton, one of the first questions we are asked is “which spray dryer(s) do you have and how much material can they produce?” Whilst these are very pertinent questions, the answer is not a simple …

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19th November 2019 – API Challenges in early stage formulation development, part 2

News 19th November 2019 – API Challenges during early formulation development, Part 2 There are many challenges that face companies taking a NCE into early stage feasibility testing and beyond. Some of these challenges are specific to the physical and chemical properties of the molecule in question (e.g. hard to handle API) whilst other challenges …

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2nd October 2019 – API Challenges in Early Stage Formulation Development, Part 1

News 2nd October 2019 – API Challenges in Early Stage Formulation Development, Part 1 There are many challenges that face companies taking an NCE into early stage feasibility testing and beyond. Some of these challenges are specific to the physical and chemical properties of the molecule in question whilst other challenges are related to the …

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10th September 2019 – Upperton Spray Drying Schedule: Autumn 2019

News 10th September 2019 – Autumn Newsletter The start of September is always a busy time in anyone’s calendar, whether you are a parent getting your children ready for school or a small CDMO looking to ramp up your development activities after the summer slowdown. Here at Upperton things are no different, September marks the …

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