Inhalation Delivery

Where particle size and performance really matters, Upperton have the expertise

Spray drying is now recognised as the best technology for engineering next generation dry power formulations with the correct aerodynamic properties needed for successful inhalation, which includes both nasal and pulmonary delivery. 

Delivery of treatments by inhalation, directly into the lungs (pulmonary) or to the nasal mucosa (nasal delivery), remains a popular approach to evoke a local or even a systemic response. Therapeutics can be delivered as dry powder or liquid, usually from pressurised or breath-actuated devices.

Particle engineering is at the core of formulation development, especially for dry powder inhalers or nasal sprays, where the aerosolisation of the powder is key to delivery of the therapeutic to the target site.

Powder and product characterisation are key for inhaled formulations, and Upperton has a range of analytical capabilities to support development activities, including;

  • Particle size by laser diffraction
  • Spray pattern and plume geometry
  • Microscopy including Scanning Electron Microscopy
  • Aerodynamic particle size distribution by cascade impactor
  • Emitted dose and content uniformity

See list of analytical techniques here.

Pulmonary

Drug delivery to the lungs remains a mainstay treatment for respiratory diseases, but there is increasing interest in delivering systemic treatments by the pulmonary route. This can especially be the case for biotherapeutics, which can take advantage of the large surface area, good blood supply, thin epithelium and avoidance of first-pass metabolism.

To reach the desired region of the respiratory system, a powder particle size of 1 – 5 µm is often required. Furthermore, a narrow particle size distribution is usually needed to increase the effective dose. Spray drying is increasingly used as a manufacturing method to produce spherical powders with excellent particle size, morphology and aerosolisation behaviour. These properties can be tailored through changes in formulation and spray drying parameters, such as feedstock concentration, atomisation pressure and temperature.

One Upperton approach is to optimise the spray drying process for product yield, with particle size no longer the primary focus. The feedstock concentration and processing rate can both be increased; significantly reducing both manufacturing time and cost. The spray dried particles are then reduced to the target particle size distribution, using a carefully controlled dry powder milling process. The result is a much faster, more efficient process producing large quantities of powders with excellent aerolisation properties.

Nasal

Drug delivery by nasal routes is usually an approach to achieve systemic delivery, making use of the thin, well vascularised nasal mucosa. Therapies delivered by this route often have very fast onset of treatment as they pass directly into the systemic blood circulation, without first-pass hepatic or intestinal metabolism.

Liquid nasal sprays are relatively common and are available for a range of indications, whilst dry powder sprays are gaining traction due to improved stability over liquid products. Whilst the target particle size for nasal powders is greater than 10 micron to avoid pulmonary delivery, spray drying can be used to produce a stable, dry powder with narrow particle size distribution. This is especially noticeable for biotherapeutics, which can be difficult to dry into discrete powders for such applications.

Pre-formulation Studies

Upperton’s formulation development team will confidently guide you on the best route forward.

Formulation Development

Utilise our expertise and know-how to solve problems unique to your challenging molecule.

Clinical Manufacturing

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